Pulsating microneedles a pain-free alternative to traditional needles

According to new research by a team from the University of Griffith University and the University of Newcastle, the needles designed to be less than 1 mm in length are painlessly entered the outer layer of the skin painlessly and the drug is given in the body.

The new transdarmal drug delivery using pulsed, fabricated microndals presents a promising option for traditional leather injections. “Healthy dried electro stretching is pulsing” (pides) method Published In the journal Small ways,

“current Construction methods Such as micro-molding, wet captures and 3D printing are often complicated, expensive and may not be ideal for some temperature-sensitive drugs, “Luan Mai, a PhD candidate and co-author of the study said Luan Mai.

“We wanted to make Microneedle Production simple, more efficient and better for drug distribution, “said Dr. UN Yong, co-writer at the University of Newcastle.

The team’s technology used a pulsed, electro-hydrodynamic force, which originated between two metal plates, which draws and shapes polymer drops into fine conical structures.

As the solvent evaporated, the polymer froze in a microndele with a sharp and rigid tip, which was ideal for penetrating the painless skin.

Researchers tested these microndals on agarose gel and pig skins, confirmed them Mechanical strength And the ability to effectively pierce the skin.

He also tested drug encapsulation using curcumin, a model compound, and demonstrated a controlled time-dependent drug release profile, confirming the compatibility of the system with physical conditions.

From the School of Engineering and Built Environment of Griffith University, Dr. Van Dau said, “Our technology represents an alternative method of Microndeale Manufacturing.”

“By integrating in situ drying with electrostraching, we have simplified the process by ensuring high performance, repetition and drug compatibility.

“Pides technology is low cost and scalable, which can make many microndals coined without compromising quality.”

Further, the team planned to explore the development of the technology further and detect the development of the on-demand Microndel array system, which aims to increase flexibility and accuracy in drug distribution applications.

Dr. Dau said that it can give rise to new routes for more accessible and patient -favorable treatment of the patient. drug deliveryHowever, the project was still in its early stages.